摘要
用阻断大鼠大脑中脑动脉及小鼠侧脑室注射角叉菜胶所致的脑水肿模型，研究神经妥乐平抗脑水肿作用及机制。结果表明，阻断大脑中动脉１５ｍｉｎ后，舌下静脉给予神经妥乐平１５，３０及１５０ＮＵ·ｋｇ－１，能减轻缺血性脑水肿；小鼠侧脑室注射角叉菜胶后即刻自尾静脉给与神经妥乐平３０，６０及３００ＮＵ·ｋｇ－１，其中３００ＮＵ·ｋｇ－１能明显减轻脑水肿。提示神经妥乐平减轻缺血性脑水肿的机制可能与其抑制激肽—缓激肽系统的作用有关。
Neurotropin, an inhibitor of the kallikrein-kinin system, has been used as an analgesic and antiallergic drug in the clinic. The aims of this study are to evaluate the effect of neurotropin on brain edema induced by permanent focal cerebral ischemia in rats and collateral ventricular injection of carrageenan in mice and its mechanism. Drugs were given iv 15 minutes after middle cerebral artery occlusion in rats and immediately after carrageenan injection in mice. Brain water content was determined by wet/dry weight ratio. Results showed that neurotropin could reduce the brain edema induced by permanent focal cerebral ischemia in rats and collateral ventricular injection of carrageenan in mice at doses of 30, 60, 300 and 300 NU·kg-1 body weight. It also suggests that neurotropin reduced ischemic brain edema via inhibiting the kallikrein-kinin system.
出处
《药学学报》
CAS
CSCD
北大核心
1998年第2期98-101,共4页
Acta Pharmaceutica Sinica
关键词
神经妥乐平
角叉菜胶
脑水肿
Neurotropin
Carrageenan
Cerebral ischemia
Brain edema
