摘要
以支撑双层类脂膜(s-BLM)作为生物膜模型,采用循环伏安法和交流阻抗技术研究了异丙酚与双层类脂膜的相互作用。结果表明,异丙酚能降低磷脂分子的有序性,诱发s-BLM上形成孔洞或缺陷,且这种相互作用对作用时间、异丙酚浓度以及胆固醇的存在与否具有依赖性。
In this paper, supported bilayer lipid membrane （s-BLM） was served as a biomembrane model. The interaction between propofol and s-BLM was investigated by means of cyclic voltammetry and ac impedance spectroscopy. The results showed that propofol could decrease the orderliness of lecithin molecule and induce pores or defects on s-BLM. The interaction depended on time, propofol concentration and cholesterol.
出处
《化学与生物工程》
CAS
2009年第3期50-52,共3页
Chemistry & Bioengineering
基金
国家自然科学基金资助项目(2067307)
关键词
支撑双层类脂膜
异丙酚
循环伏安
交流阻抗
supported bilayer lipid membrane
propofol
cyclic voltammetry
ac impedance spectroscopy
