摘要
目的探索急性混合细胞白血病人类白细胞抗原（HLA）单倍体造血干细胞移植治疗方法及疗效观察。方法对4例急性混合细胞白血病患者进行HLA单倍体外周血造血干细胞联合骨髓移植治疗，观察移植疗效及相关并发症。结果所有患者均成功重建造血。中性粒细胞及血小板恢复中位时间分别为16．5d（14～21d）、16．5d（15～30d）。1例PR患者移植后完全缓解，其余3例持续缓解。2例移植过程中发生急性GVHD，未观察到慢性GVHD的发生。1例患者在移植过程中发生单一的APTT延长。中位随访时间181d（129～337d），1例于移植后190d死于真菌感染，1例CR2和1例PR分别于移植后183d和129d病情复发，另1例无病存活337d。结论HLA单倍体外周血造血干细胞联合骨髓移植治疗急性混合细胞白血病切实可行，但需积累更多的资料以进一步观察疗效。
Objective To explore the way for the treatment of acute mixed lineage leukemia （AMLL） with HLA haploidentical blood stem cells and to detect the efficacy. Methods The transplantation with HLA haploid peripherad blood stem cells and bone marrow for four patients with AMLL were carried out,and the efficacy and correlated complication were observed. Results All patients were successful engraftment. The median days of white blood cell （ANC〉0.5 × 10^9/L） and platelet（〉20 × 10^9/L） were 16.5 （14-21）d and 16.5 （15- 30）d, respectively. One patient with partial remission（PR） was complete remission（CR） and the other three patients were continue complete remission after transplantation. Actue GVHD occurred in two patients. Chronic GVHD was not seen. Single prolong of APTT was detected in one patient. The median follow-up duration was 181 （129-337）d. One died with fungus infection posttransplantation 190d. One patient with CR2 and one with PR was relapse posttransplantation 183d and 129d,respectively. The other one was free-disease survival for 337d. Conclusion It is feasible to treat AMLI. with co-transplantation of HLA-haploidentical peripheral blood stem cells and bone marrow,but more cases should be observed for the efficiency.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第5期564-566,共3页
Chongqing medicine
基金
重庆市医学重点学科建设基金资助项目(2006C028)
第三军医大学新桥医院"1520人才培养工程"专项基金资助项目(2006)。
关键词
急性混合细胞白血病
人白细胞抗原
单倍体
外周血造血干细胞
骨髓移植
acute mixed lineage leukemia
human leukocyte antigen
haploid
peripherad blood stem cells
bone marrow
transplantation
