摘要
目的确保重庆市首例非血缘异基因外周血干细胞移植(URD-PBSCT)治疗慢性粒细胞白血病成功。方法对接受URD-PBSCT的慢性粒细胞白血病患者移植过程进行总结分析。结果患者造血重建迅速,中性粒细胞>0.5×109/L,血小板>20×109/L的时间分别为+13d、+16d,+17d患者的血型由O型转变为供者的B型,并经STR复检证实患者的性染色体由XY转为供者型的性染色体XX;移植过程中未见GVHD、VOD等严重并发症,骨髓细胞bcr/abl融合基因于+27d检查完全消失,+100d再次复查仍为阴性。结论重庆市首例URD-PBSCT治疗慢性粒细胞白血病患者获得圆满成功,URD-PBSCT可成为某些白血病得以根治的重要手段。
Objective To insure success of unrelated-donor peripheral blood stem cell transplantation（URD-PBSCT）for patient with CML at the first time in chongqing. Methods To summarize and analyse the whole couse of URD-PBSCT for patient with CML. Results The patient was engrafted and hematopoieteic reconsthution was rapid： the mean days of ANC recovery were 13d up to 0.5〉 10^9/L and PLT was 16d up to 〉20 10^9/L;the blood type B was 17d began to transform, the sex chromosome was XX by STR method; the bcr/abl gene checked on 27d and 100d in bone marrow cells were disappear; the acute GVHD and VOD were not seen. Conclusion Our study suggests that URD-PBSCT is an effective therapeutic option for CML patients.
出处
《重庆医学》
CAS
CSCD
2005年第9期1283-1285,共3页
Chongqing medicine
