摘要
目的检测膀胱癌组织中缺氧启动子（HIF）-1α的表达，探讨HIF-1α在膀胱癌中表达的临床意义。方法应用免疫组织化学方法检测80例膀胱癌组织中HIF-1α的蛋白表达，并分析其表达与肿瘤临床特征及复发的关系。结果30例正常膀胱组织未发现HIF-1α阳性表达，80例膀胱癌组织中有43例HIF-1α表达阳性，阳性表达率占53．75％。其表达与肿瘤的大小、部位、数目、病理分级以及患者年龄无关，但与肿瘤的临床分期及复发明显相关。结论在膀胱癌中，HIF-1α的表达均明显上调，HIF-1α在膀胱癌的侵袭等生物学过程中具有重要的作用。
Objective To investigate the clinicopathological significance of HIF-1αlpha expression in bladder cancer. Methods HIF-1αlpha protein expression in 80 cases of bladder cancers was detected by using immunohistochemistry. The relationship between the HIF-1αlpha expression and various clinicopathological parameters including clinical features of bladder cancer and recurrence was analyzed. Results Over-expression of HIF-1αlpha was frequently （43 of 80 cases,53.75% ） detected in bladder cancer, whereas no HIF-1 αlpha expression was detectable in 30 normal bladder tissues. HIF-1 alpha expression was significantly correlated with invasion of bladder cancer, but not with pathological grade. Conclusion HIF-1 αlpha is frequently expressed in bladder cancer. HIF-1αlpha may play a critical role in the invasion of bladder cancer and can be used to estimate the progression of bladder cancer.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2009年第3期361-362,共2页
Chinese Journal of Experimental Surgery
