摘要
目的建立适合微波消融的兔肺肿瘤模型。方法新西兰大白兔36只,CT引导下穿刺,将载有VX2肿瘤组织悬液的亲水凝胶接种于右肺内。结果接种后14～26d,CT检查证实34只新西兰大白兔肺内有肿瘤生长,其中26只呈单发结节,直径0.5～0.8cm,兔肺VX2肿瘤模型成功率为72.2%(26/36);另有2只肺内呈多发结节生长,并出现胸腔积液;4只累及纵隔;2只出现胸壁种植转移。接种过程未出现气胸、出血等并发症。结论本实验建模方法安全、有效,并可在肺内局部形成较大体积的实体瘤,能满足微波消融治疗肺癌的研究需要,因此所建兔肺VX2肿瘤模型是成功的。
Objective To establish rabbit lung tumor model suitable for microwave ablation. Method Under CT guidance, 36 New Zealand white rabbits were implanted with hydrogel containing VX2 tissue suspension to the right lung. Results Fourteen to twenty-six days after implantation, tumors were found in 34 rabbits by CT scan. Twenty-six of them had single nodule in right lung, with a diameter from 0.5 cm to 0.8 cm. The achievement rate of model establishment was 72.2% （26/36）. Multi-nodules occurred in 2 rabbits associated with pleural effusion. Mediastinum was involved in 4 rabbits and thoracic wall implantations were found in 2 rabbits. No complication of pheumothorax and bleeding occurred during the procedure. Conclusion The rabbit lung VX2 tumor models are established successfully with enough tumor volume for the study of the microwave ablation; and furthermore the method is safe and feasible. （J Intervent Radio1, 2009, 18 ： 141-143 ）
出处
《介入放射学杂志》
CSCD
北大核心
2009年第2期141-143,共3页
Journal of Interventional Radiology
