摘要
目的了解中国人结直肠癌p53基因缺失的情况。方法应用Southern印迹杂交技术检测24例结直肠癌p53基因缺失。结果发现24例结直肠癌中10例(41.7%)存在p53基因缺失,且发生淋巴结扩散和远处转移的结直肠癌中,p53基因缺失率较高(分别为60%和66.67%)。结论 p53基因缺失是结直肠癌的一种常见的分子结构改变,可能在结直肠癌的发生和发展中起着重要的作用。
Objectives To investigate the deletion of p53 gene of colorectal cancer in Chinese. Methods South- ern blot method was used to detect p53 gene deletion in 24 patients with colorectal cancer. Results Of 24 cases tested, 10 were p53 gene deletion positive which yield a total deletion rate of 41.7% and p53 gene deletion rate was found higher in tumour with lymphatic infiltrating or remote metastasis than without in- volvement. Conclusion p53 gene deleiton was a frequent molecular structural change and may play an important role during colorectal carcinogenesis.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1998年第1期40-41,共2页
Chinese Journal of Experimental Surgery
