摘要
目的 探讨CD44V6在宫颈癌中表达与肿瘤转移及患者预后的关系。方法 应用免疫组化方法检测15例正常宫颈组织、30例宫颈上皮瘤样病变、58例浸润宫颈癌中CD44V6蛋白表达。结果 CD44V6阳性表达在正常宫颈组织、宫颈上皮瘤样病变及浸润宫颈癌呈逐渐增高趋势,宫颈上皮瘤样病变及浸润宫颈癌CD44V6蛋白阳性表达与正常宫颈组织比较有显著性差异(P<0.05)。CD44V6蛋白在浸润型宫颈癌阳性表达明显高于宫颈上皮瘤样病变(P<0.05)。浸润型宫颈癌CD44V6蛋白表达与患者的年龄、肿瘤大小、组织分级、预后无关,CD44V6蛋白阳性表达与有无淋巴结转移密切相关(P<0.05),浸润深度≥1cn CD44V6蛋白阳性表达明显高于浸润深度<1cm (P<0.05),Ⅱ期宫颈癌中CD44V6蛋白表达明显高于Ⅰ期(P<0.05)。结论 CD44V6在宫颈癌的发生、发展中起重作用,并且与肿瘤的浸润转移密切相关,可作为临床预测浸润转移的一个重要参考指标。
Objective To study the expressive of CD44V6 protein in invasive carcinoma of cervix and its significance.Methods The expression of Cd44V6 protein of 15 normal cervial epithelium (NCE),30 cervical intraepithelium neoplasia (CIN),58 invasive carcinoma of cervix (ICC) were detected by immunohistochemical method.Results 1. The positive expression of CD44V6 in CIN and ICC was significantly different to that of in NCE (P<0.05).2. The positive expression of CD44V6 in CIN was significantly different from that of in ICC (P < 0.05) .2. The was no significant correlation between CD44V6 and patient age,tumor size,tumor differentiation and prognosis ( P < 0.05) 3. There was significant correlation between CD44V6 and lymph nodes metastasis,invasive depth ( P < 0.05) .4. The positive expression of CD44V6 in stage Ⅱ was significantly higher than that in stage I . There was significantly difference ( P < 0.05).Conclusion There was a close correlation between expression of CD44V6 and generation and development in the ICC. The expression of CD44V6 may serve as an indicator to predict the invasion and lymph nodes metastasis of invasive carcinoma of cervix.
出处
《实用肿瘤学杂志》
CAS
2004年第2期104-106,共3页
Practical Oncology Journal
