摘要
目的观察碘化油协同高功率聚焦超声(HIFU)杀伤裸鼠皮下LTNM_4肝癌疗效。方法碘化油以0.3～0.4ml/只行瘤内直接注射,国产HIFU样机以1.1MHz、750W/cm^2、20s照射。结果 HIFU照射组Ⅲ和碘化油注射+HIFU组Ⅲ显著抑制肿瘤生长,治疗后第4周,抑瘤率分别为87%和93%,较对照组Ⅰ和单纯碘化油注射组Ⅱ有显著性差异(P<0.05)。Ⅲ组、Ⅳ组生存期较Ⅰ组和Ⅱ组明显延长(P<0.05)。结论 HIFU能有效破坏肝癌组织,碘化油协同HIFU治疗具有潜在的增效、定位和导向作用。
Objective To observe the efficacy of high-intensity focused ultrasound (HIFU) combined with iodized oil to treat primary liver cancer LTNM_4 implanted subcutaneously in the nude mice. Methods Forty-eight nude mice bearing tumor were randomly divided into 4 groups. Intratumor direct injection of iodized oil and HIFU exposure with a focused 1. 1 MHz transducer with a peak intensity of 750 W/cm^2 were performed. Results Significant inhibition of the tumor growth was shown in the group Ⅲ and group Ⅳ as compared with group Ⅰ or group Ⅱ (P<0.05), with the tumor growth inhibition rate at the 28th day after the treatment being 87% and 93%, respectively. Significantly improved survival time was noted in group Ⅲ and group Ⅳ as compared with those of group Ⅰ and group Ⅱ (P<0.05). Histologi- cally, group Ⅳ revealed tumor necrosis more completely than that of group Ⅲ. Conclusion These find- ings suggest that HIFU combined with iodized oil might have potential functions of synergism, location and targeting in the treatment of liver cancer.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1998年第1期23-24,共2页
Chinese Journal of Experimental Surgery
基金
美国中华医学基金会
