摘要
目的：研究神经提取液对失神经肌肉的保护作用。方法：将坐骨神经提取液（ＳＥ）与中枢神经提取液（ＣＥ）应用至ＳＤ大鼠失神经趾长伸肌（ＥＤＬ）中，检测其湿重、总蛋白、钙离子浓度、生理学与组织学指标的变化，并对ＳＥ、ＣＥ、失神经肌肉的蛋白成分进行初步分析。结果：ＳＥ与ＣＥ对失神经ＥＤＬ最大强直收缩力（ＰＯ）与强直收缩后动作电位（ＰＴＰ）的降低、舒张期时程（ＲＴ）的延长、肌肉总蛋白与钙离子的下降、肌湿重与肌纤维截面积的减少有保护作用。结论：ＳＥ与ＣＥ对失神经的肌肉具有保护作用。
bjective: To study the protective effects of extracts on denervated muscle. Method: Sciatic nerve extract (SE) and central nerve extract (CE) were injected into the denervated extensor digital longus muscle (EDL) of the SpragueDawley rats, the muscle wet weight, total protein, Ca2+, physiologic responses and morphology level were measured,the protein band of SE and CE and denervated muscle were also analysed. Results: The SE and CE can raise the tetanic tension(PO), posttetanic twitch potentiation(PTP), muscle total protein, Ca2+ and muscle fibre crosssection area (CSA) of the denervated muscle, and the prolonged muscle relaxation time (RT) caused by denervation can be shortened. Conclusion: The SE and CE have protective effects on denervated muscle.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1998年第1期36-38,共3页
Chinese Journal of Orthopaedics
