摘要
目的：研究中枢神经的有效物质对失神经肌肉的作用。方法：在ＳＤ大鼠失神经趾长伸肌中，应用中枢神经提取液（ｃｅｎｔｒａｌｎｅｒｖｅｅｘｔｒａｃｔ，ＣＥ），并观察肌肉萎缩的生理学指标。结果：肌肉失神经后的最大强直收缩力（ｔｅｔａｎｉｃｔｅｎｓｉｏｎ，ＰＯ）及强直收缩后动作电位（ｐｏｓｔｅｔａｎｉｃｔｗｉｔｃｈｐｏｔｅｎｔｉａｔｉｏｎ，ＰＴＰ）下降，舒张期时程（ｒｅｌａｘａｔｉｏｎｔｉｍｅ，ＲＴ）延长，肌湿重、肌肉总蛋白及肌纤维截面积（ｃｒｏｓｓ－ｓｅｃｔｉｏｎａｒｅａ，ＣＳＡ）的减少，均可被中枢神经提取液有效地缓解。
Objective: To study the effective materials of central nerve extract(CE) on denervated muscle. Methods: The CE was applied into the denervated extensor digital longus muscle (EDL) of the SD rats, and the indexes of muscle atrophy were observed. Results: The decrease of tetanic tension (PO), posttetanic twitch potentiation (PTP), and the lengthening of relaxation time (RT) of the denervated EDL could be ameliorated by CE. The decrease of muscle wet weight, total protein and muscle fibre cross section area (CSA) after denervation could be prevented by CE. Conclusion: The atrophy of denervated muscle could be ameliorated by CE.
出处
《中华手外科杂志》
CSCD
1997年第1期46-48,共3页
Chinese Journal of Hand Surgery
基金
美国中华医学基金
关键词
肌肉骨骼系统
中枢神经提取液
周围神经
Muscle oskeletal system Central nerve medicine Peripheral nerve
