摘要
目的探讨雌激素受体β（ERβ）基因多态性与原发性肝癌的关系。方法选择西南地区100例原发性肝癌患者为观察组，100例同期非肝病患者作为对照组。应用分子生物学的限制性片段长度多态性方法分析Rsa I和Alu I，观察ER β基因型的分布。结果观察组R等位基因频率为35．0％，对照组为51．0％，OR值0．517（95％可信区间为0．346～0．773），P〈0．01。观察组A等位基因频率为20．5％，对照组为11．0％，OR值2．086（95％可信区间为1．191～3．654），P〈0．01；Rsa I和Alu I限制性片段长度多态性在两组中均呈多态性分布。结论ERD基因多态性与原发性肝癌有关，R等位基因可能是其保护因素，A等位基因可能是其危险因素。
Objective To investigate whether there is a association between estrogen receptor beta （ER β ） gene polymorphism and primary hepatocellular carcinoma （HCC）. Methods 100 primary HCC patients and 100 controls from southwestern China were recruited in this study. The polymorphism of RsaI and AluI in ER β gene was analyzed by PCR-restriction fragment length polymorphism （RFLP）. Results R allelic frequency was 35.0% and 51.0% in HCC patients and in control group, respectively, odds ratio （OR） was 0.517 [95% confidence intervals （CI） = 0.346-0.773], P 〈 0.01. A allelic frequency was 20.5% and 11.0% in HCC patients and in control group, respectively, OR was 2.086 （95% CI = 1.191-3.654）, P 〈 0.01. Gene frequency of RsaI and AluI in the two groups was distributed with polymorphism. Conclusion ER β gene polymorphism is associated with primary liver cancer. R allele may be the guard factor, and A allele may be its risk factor.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2009年第2期99-101,共3页
Chinese Journal of Hepatology
关键词
癌
肝细胞
原发性
受体
雌激素
等位基因
基因多态性
Carcinoma, hepatocellular, primary
Receptor, estrogen
Allele
Gene polymor-phism
