摘要
目的探讨雷洛昔芬对去卵巢大鼠血压的影响。方法40只12周龄雌性SD大鼠随机均分为5组:去卵巢组、假手术对照组、雌激素组(倍美力,1mg·kg-1·d-1)、小剂量雷洛昔芬组(易维特,1mg·kg-1·d-1)和大剂量雷洛昔芬组(易维特,3mg·kg-1·d-1),测量治疗前、后各组血压的变化。结果去卵巢组血清雌二醇水平显著低于假手术对照组,雌激素或雷洛昔芬治疗后雌二醇水平都上升(P<0.01)。卵巢切除前5组大鼠之间的收缩压差异无统计学意义,3个月后去卵巢组收缩压明显升高,高于治疗前及治疗后其他各组收缩压的水平。雌激素或雷洛昔芬治疗后,收缩压水平下降,低于去卵巢组[治疗后:去卵巢组(128.46±15.78)mmHg,假手术对照组(104.48±15.03)mmHg,雌激素组(106.83±13.52)mmHg,小剂量雷洛昔芬组(109.55±11.23)mmHg,大剂量雷洛昔芬组(107.57±17.56)mmHg,P<0.01]。结论雷洛昔芬可降低去卵巢大鼠收缩压水平,有助于降低绝经后的心血管危险。
Objective To investigate the effect of raloxifene on blood pressure in ovariectomized rats. Methods Forty twelve-week old female Sprague-Dawley rats were randomly divided into five groups：ovariectomy, sham operation, ovariectomy ＋ estrogen（ 1 mg·kg^-1·d^-1）, ovariectomy ＋ small dose raloxifene（ 1 mg·kg^-1·d^-1）, ovariectomy ＋ large dose raloxifene （3 mg·kg^-1·d^-1 ）. Serum estradiol and blood pressure were measured before and after three months treatment. Results Serum estradiol was significantly lower in ovariectomized rats than that in sham operated animals. Serum estradiol was increased after the treatment of raloxifene （P〈0.01）.The systolic blood pressure （SBP） was significantly higher in ovariectomized rats than that of other groups, SBP was decreased after the treatment of raloxifene（P〈0.01 ）. [ after treatment OVX ： （ 128.46±15.78）mm Hg vs Control ： （ 104.48±15.03 ）mm Hg vs E （106.83±13.52）mm Hg vs Rs：（109.55±11.23）mm Hg vs R1：（107.57±17.56） mm Hg,P〈0.01）. Conclusion Raloxifene could decreased the blood pressure of ovariectomized rats, and may be benefet in the prevention of cardiovascular disease.
出处
《中国心血管病研究》
CAS
2007年第11期842-844,共3页
Chinese Journal of Cardiovascular Research
关键词
雷洛昔芬
雌激素类
受体
雌激素
血压
大鼠
Raloxifene
Estrogens
Receptors, estrogen
Blood pressure
Rat
