摘要
目的：探讨Ⅲ型肠化与异型增生的关系。方法：采用粘液组化技术将胃粘膜肠化标本分为Ⅰ、Ⅱ、Ⅲ型。盲法比较肠化亚型和异型增生的形态学差异；Ａｇ－ＮＯＲｓ技术定量分析肠化亚型和异型增生细胞Ａｇ－ＮＯＲｓ计数差异。结果：８６％（３７／４３）的Ⅲ型肠化符合轻度异型增生诊断标准；Ⅰ型和Ⅱ型肠化无一例符合（Ｐ＜００００１）；Ａｇ－ＮＯＲｓ计数Ⅲ型肠化（４３３±０８６）显著大于Ⅰ型（２９３±０９２）和Ⅱ型（３１３±０６９）（Ｐ＜００１），但与异型增生（４１４±１４５）差异无显著性（Ｐ＞００５）。结论：Ⅲ型肠化是异型增生的一种类型。
Aims:To study the relationship between type Ⅲ intestinal metaplasia and gastric dysplasia.Methods: Mucin histochemistry was applied to gastric biopsy specimens to classify gastric intestinal metaplasia (IM) into three types:type Ⅰ,Ⅱ and Ⅲ,followed by judging whether the subtypes of IM fulfil the nuclear and architectural criteria for gastric dysplasia blindly .The Ag-NORs technique was also applied to futher investigate the difference in Ag-NORs count between the subtypes of IM and gastric dysplasia .Results: 37 of 43(86%) cases of type Ⅲ fulfiled the criteria for mild gastric dysplasia ,compared to none of type Ⅰand Ⅱ(P<0.0001).The AgNORs was significantly higher in type Ⅲ(4.33±086) than type Ⅰ (293±0.92) and Ⅱ (313±0.69)(P<0.01),but not than in dysplasia (4.14±1.45)(P<005).Conclusion: Our findings suggest that type Ⅲ IM is a type of dysplasia and may be a premalignant lesion.
出处
《胃肠病学和肝病学杂志》
CAS
1998年第1期53-57,共5页
Chinese Journal of Gastroenterology and Hepatology
关键词
肠上皮化生
异型增生
粘液组化
胃肿瘤
Intestinal metaplasia ,Gastric dysplasia,Gastric cancer,AgNORs. Mucin histochemistry
