摘要
目的：探讨单纯慢性浅表性胃炎（ＣＳＧ）和慢性糜烂性胃炎（ＣＥＧ）与组织学的相关性以及二者与幽门螺杆菌（Ｈｐ）、胃泌素（Ｇａｓ）和表皮生长因子（ＥＧＦ）的关系。方法将内镜下１０８例慢性非萎缩性胃炎分为单纯ＣＳＧ７８例和ＣＥＧ３０例。以盲法方式由一位病理医生阅片，将慢性炎症和异型增生（Ｄｙｓ）分为轻、中、重度；粘液组化染色将肠化（ＩＭ）分为Ⅰ、Ⅱ、Ⅲ型；Ｈｐ以胃粘膜Ｇｉｅｍｓａ染色和１４Ｃ－ＵＢＴ确定；放免法测定Ｇａｓ和ＥＧＦ。结果单纯ＣＳＧ轻、中、重度慢性炎症分别为４６（５９％）、１４（１８％）和１８（２３％），ＣＥＧ分别为１６（５３％）、８（２７％）和６（２０％），差别无显著性（Ｐ＞０．０５）；两种胃炎的ＩＭ、Ｄｙｓ和Ｈｐ的检出率也无显著性差别，分别为２５６％ｖｓ３３．３％、１３％ｖｓ１３３％和３８５％ｖｓ２０％（Ｐ＞０．０５）。ＣＥＧ的ＥＧＦ含量显著低于单纯ＣＳＧ（１３８±０．２１ｎｇ／ｖｓ０．８９±０．１４ｎｇ／ｍｌ，Ｐ＜０．０５），而Ｇａｓ含量二者差别无显著性（９５７±２３．１ｐｇ／ｍｌｖｓ９８．２±２５．３ｐｇ／ｍｌＰ＞０．０５）。结论内镜下单纯ＣＳＧ和ＣＥＧ仅代表两种不同的慢性胃炎类型?
Aim To investigate the relationship of simple chronic superficial gastritis(CSG) and chronic erosive gastritis(CEG) with histology,and Helicobacter pylori(Hp) infection and gastrin (Gas) and epidermal growth factor (EGF) Methods 108 patients with chronic nonatrophic gastritis were classified into 78 cases of simple chronic superficial gastritis and 30 chronic erosive gastritis.All the slides were examined by a single blind pathologist and grade mild to severe for the presence of chronic inflammation and gastric dysplasia(Dys).Mucin histochemistry was applied to classify gastric intestinal metaplasia(IM)into three types:type ,type and type ,and the presence of Hp was determined by Giemsa staining in gastric biopsy specimens and 14Curea breath test,and serum Gas and EGF were measured by radioimmunoassay. Results The number of mild,moderate and severe chronic inflammation shown 46(59%),14(18%)and 18(23%),respectively,in CSG was not statistically different from 16(53%),8(27%)and 6(20%),respectively,in CEG(P>0.05).There was also no difference between CSG and CEG in incidence of IM(25.6% vs 33.3%%),Dys(1.3% vs 13.3%)and Hp(38.5% vs 20%)(P>0.05).Serum EGF was reduced in CEG compared to CSG(1.380.21 ng/nl vs 0.890.14 ng/ml,P<0.05),and there was no difference in serum Gas between CSG and CEG(95.723.1 pg/ml vs 98.225.3 pg/ml P>0.05). Conclusion Simple CSG and CEG under endoscopy does not correlated with the degree of inflammation of the gastric mucosa that was identified only by histopathology,but represent two different type of chronic gastritis.The reduction of serum EGF may play a role in the pathogenesis of CEG.
出处
《胃肠病学和肝病学杂志》
CAS
1999年第2期113-116,共4页
Chinese Journal of Gastroenterology and Hepatology
关键词
慢性
胃炎
组织学
幽门螺杆菌
表皮生长因子
chronic gastritishistologyHelicobacter pylorigastrinepidermal growth factor
