摘要
目的：探讨成人急性杂合型白血病（ＨＡＬ）的临床及生物学特征。方法：对１８例ＨＡＬ进行了免疫分型、核型分析及临床特征研究。结果：ＨＡＬ主要可以分成四组：（１）Ｂ、髓混合型，１０例；（２）Ｔ、髓混合型，１例；（３）Ｔ、Ｂ、髓三系混合型，３例；（４）Ｔ、Ｂ混合型，４例。１２例核型分析者中，８例（６７％）显示克隆性异常，其中４例Ｐｈ染色体阳性，３例高度复杂异常。ＨＡＬ患者高白细胞及脾肿大多见、ＣＤ３４及多药耐药Ｐ－糖蛋白高表达。２７．８％的患者获完全缓解，中位生存期３月。结论：成人ＨＡＬ具有多种不良预后因素，针对急性淋巴细胞白血病及急性髓细胞白血病的联合化疗方案可能改善ＨＡＬ患者的预后。
Objective: To explore the clinical and biological features of patients with hybrid acute leukemia (HAL) in adults. Methods: In 18 cases with HAL, immunophenotyping and karyotyping were performed and clinical data were collected. Results: The cases were distributed in four groups: (1) coexpression of myeloid and B antigens, 10 cases; (2) one case coexpressed myeloid and T antigens; (3) three cases with trilineage involvement; (4) four cases with coexpression of both B and T cell antigens. Cytogenetic analysis was performed in 12 cases, of which 4 were Philadelphia chromosome positive and 3 had complex karyotype abnormalities. High white blood cell counts、 splenomegaly、 high expression of both CD34 and multidrug resistance associated P-glycoproitein were frequently seen in HAL patients. 27.8 percent of cases achieved complete remission, and the median survival was three months. Conclusions: Adult HAL had distince clinical and biological features which were associated with poor prognosis. Combination chemotherapy directed against acute lymphoblastic and acute myeloid leukemia might improve the prognosis.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1998年第3期201-203,共3页
Chinese Journal of Cancer
关键词
杂合型
白血病
免疫表型
细胞遗传学
Hybrid acute leykemia Immunophenotype Cytogenetics Prognosis
