摘要
用流式细胞仪检测21例t（8；21）易位急性髓细胞性白血病细胞的免疫学表型，并与无t（8；21）易位急性髓细胞白血病（M2）病人比较．结果：t（8；21）+组与t（8；21）-组CD1，阳性率分别为62％、9％（P＜0．01）．CD34阳性率分别为76.2％、36％（P＜0．05），t（8；21）+组中皆无表达CD7，而t（8；21）-组中CD7阳性率为27．2％（P＜0．05）；两组间CD15、CD13、CD33、CD10表达无显著差异．提示t（8；21）急性髓细胞白血病有独特的免疫学表型特点，对形态学分类法难以分类的急性白血病诊断有一定的价值．
Immunophenotyping in 21 cases of acute myeloid leukemia (AML) with t(8; 21) translocation was dtected on flow cytometry and was compared with AML(M2) without t(8 ; 21) translocation. The results showed CD19 positivity rate in t (8; 21 )+ group and t (8; 21 )- group were 62%, 9% respectively (p < 0. 01 ) CD34 positivity rate were 76. 2%, 4% respectively (P). ) % ). There was no signficant difference between CD15, CD13 and CD33 expression. CD7 expression wasn' t detected in t (8 ; 21 )+ group. The study suggested that AML with t (8 ; 21 )translocation had unique immunophenotyping characteristics which were of some diagnosis value to AML that was difficult to classisify in FAB.
出处
《苏州医学院学报》
1997年第3期401-402,共2页
Acta Academiae Medicinae Suzhou
关键词
白血病
髓细胞性
急性
免疫学
表型
染色体
Leukemia
myeloid
acute
immunophenotype
t(8
21) translocation
