摘要
目的探讨益气养阴活血法对2型糖尿病患者血栓前状态血管内皮损伤的干预作用。方法选择有血栓前状态的2型糖尿病患者60例,将其随机分为对照组和治疗组,各30例,两组均常规给予基础治疗,治疗组另加用益气养阴活血复方——丹蛭降糖胶囊,治疗3个月。观察两组患者治疗前后血糖、血脂、血管性假血友病因子(vWF)、血栓调节蛋白(TM)水平及血液流变学指标的变化。结果治疗后治疗组患者三酰甘油、高密度脂蛋白、vWF、TM水平及全血比高切黏度、血浆比黏度、血细胞比容与对照组比较,差异均有统计学意义(P<0.05)。结论益气养阴活血法可改善糖尿病患者体内的血栓前状态,有效减轻血管内皮损伤,提示其机制可能与其调节脂代谢紊乱、降低vWF和TM水平、改善血液流变学异常有关。
Objective To observe the intervention effects of reinforcing qi nourishing yin promoting blood circulation on impaired blood vessel endothelium in piothrombotic state of type 2 diabetes mellitus. Methods Sixty patients with diabetes mellitus in prethrombotic state were selected and divided randomly into treatment group （ n = 30 ） and control group （ n = 30 ）. Both groups were treated with conventional therapeutic methods of western medicine, and treatment group with additional Chinese Medicine method of reinforcing qi nourishing yin promoting blood circulation. The therapy lasted three months. The levels of blood glucose （ BG）, blood fat, von Wilebrand factor （vWF） and thrombomduline （TM） and the changes of hemorrheology in- dex were detected before and following treatment. Results Treatment group improved siguifichntly triglyeride （TG） , high - density lipoprotein （ HDL）, vWF, TM, whole high viscosity, plasma specific viscosity and hematocrit after treatment when compared with control （ P 〈 0. 05 ）. Conclusion Method of reinforcing qi nourishing yin promoting blood circulation can amel- iorate prothrombotic state in diabetic patients, reduce efficiently the impairment of blood vessel endothelium, suggesting that its mechanism may be associated with its reduction of BG, regulation of lipid disorders, reduction of vWF, TM levels, and im- provement of abnormal hemorheology.
出处
《中国全科医学》
CAS
CSCD
北大核心
2009年第4期272-274,共3页
Chinese General Practice
基金
国家中医药管理局新药开发专项课题(06-07LP22)
安徽省"十一五"科技攻关课题(08010302184)
关键词
糖尿病
2型
益气养阴活血
血栓形成
内皮
血管
Diabetes mellitus, type 2
Reinforcing qi nourishing yin promoting blood circulation
Thrombosis
Endothclium, vascular
