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人类免疫缺陷病毒Ⅰ型慢病毒载体在脑梗死基因治疗中的应用 被引量：1

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摘要 脑梗死的主要病理生理改变是能量耗竭、酸中毒、细胞内钙离子超载、氧自由基损伤、兴奋性氨基酸毒性、炎症细胞因子损害等。基因治疗则通过理想载体将目的基因导入脑组织内，通过目的基因的表达阻断上述病理生理过程，达到减轻缺血后脑损伤、促进神经功能恢复的目的。神经元是终末分化细胞，具有不可再生的特性。以神经元为靶细胞的基因治疗，对基因转移载体的要求更为严格。以人类免疫缺陷病毒Ⅰ型（HIV-Ⅰ）基因组为基础构建的HIV—Ⅰ慢病毒载体具有感染分裂细胞及非分裂细胞（包括神经元）的能力，
作者 李霞 马学玲 刘亢丁
机构地区 吉林大学第一医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2009年第1期60-62,共3页 Chinese Journal of Neurology
基金 国家自然科学基金资助项目（30770755）
关键词 人类免疫缺陷病毒 慢病毒载体 基因治疗 脑梗死 Ⅰ型 兴奋性氨基酸毒性 病理生理改变 氧自由基损伤
分类号 R686 [医药卫生—骨科学]
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参考文献21

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二级参考文献29

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共引文献22

同被引文献24

  • 1赵丽静,刘亢丁.血管内皮细胞生长因子治疗缺血性脑卒中的新思路[J].中华临床医师杂志（电子版）,2011,5(7):2022-2025. 被引量：11
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  • 3Yang SH,Park MJ,Yoon IH. Soluble mediators from mesenchymal stem cel s suppress T cel proliferation by inducing IL-10[J].Experimental and Molecular Medicine,2009,(05):315-324.
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中华神经科杂志
2009年 第1期

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