摘要
慢病毒载体 (lentiviralvector,LV)具有可感染非分裂细胞、转移基因片段容量较大、目的基因表达时间长、不易诱发宿主免疫反应等优点 ,成为目前较有前途的病毒载体。本文以人类免疫缺陷病毒Ⅰ型 (HIV Ⅰ )为代表 。
As lentiviral vector holds the characteristics of higher transfection to non dividing cells, larger capacity of transfer gene fragments, long term expression of therapeutic gene and lower rate of immunological response, therefore it becomes potential viral vector in gene therapy. Improvements of lentiviral vector, human immunodeficiency virus type Ⅰ as example, and its application in gene transfer for gene therapy of hematological diseases are emphasized in this review.
出处
《中国实验血液学杂志》
CAS
CSCD
2003年第2期208-212,共5页
Journal of Experimental Hematology
