摘要
[目的]观察健脾补肾法对拉米夫定治疗慢性乙型肝炎(CHB)的增效作用及其与辅助性T细胞Th1/Th2的相关性。[方法]120例CHBE-抗原阳性患者,随机分为2组,观察组采用健脾补肾中药联合拉米夫定治疗,对照组仅用拉米夫定治疗,定期观察肝功能、乙肝三系、乙肝病毒核酸(HBV-DNA)、酪氨酸-蛋氨酸-天门冬氨酸-天门冬氨酸(YMDD)变异等指标,疗程均为1a。疗程结束后2组各随机抽取30例,采集外周血检测干扰素γ(IFN-γ)和白细胞介素4(IL-4)。[结果]观察组与对照组相比,在缩短肝功能、病毒载量恢复时间,提高E-抗原(HBeAg)转换率、延长YMDD变异时间等方面均有统计学意义(均P<0.05);观察组治疗后IFN-γ明显高于对照组,IL-4明显低于对照组,差异均有统计学意义(均P<0.05)。[结论]健脾补肾中药能够提高拉米夫定治疗CHB的疗效,其与Th1/Th2相关。
[Objective]To observe the synergy effect of Jianpi Bushen metod on Chronic hepatitis B treated by Lamivudine and the relationship with Th1/Th2. [Methods]One huadred and twenty patients, with HBeAg positive were divided into two groups at random： observation group and control group, each group having sixty patients. Patients in the control group were only given to Lamivudine . Patients in the observation group were given to Lamivudine and traditional Chinese drug. Observation item： liver function, HBV-DNA, HBeAg , YMDD. Thirty patients were selected from each group to detect IFN-γ and IL-4 after treatment. [Results]The rate of HBeAg divert,YMDD variation, liver function and HBVDNA load were significantly different than those of control group. IFN-γ of observation group was higher than those of control group（P〈0. 05）, but IL-4 of observation group was lower than those of control group（P〈0.05）[Conclusion ]Jianpi bushen method can significantly improve the curative effect of ehronical hepatitis B treated by Lamivudine and reduce the YMDD variation. One of the mechanism may be related with Th1/ Th2.
出处
《中国中西医结合消化杂志》
CAS
2008年第6期365-367,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
浙江省科技厅一般项目(2006C33007)
