摘要
慢性乙型肝炎是由乙型肝炎病毒感染所致的以免疫功能异常为主要机制的肝脏疾病,需要通过抗病毒和调控免疫的协同治疗来清除受感染的肝细胞并建立长期的病毒控制。现代医学研究表明,HBV免疫耐受与免疫力低下有关,与祖国医学中“正虚”概念密切相关。从中医药对慢性乙型肝炎固有免疫(自然杀伤细胞、树突细胞、肝脏巨噬细胞)和适应性免疫(调节Th1/Th2平衡、调节CD_(4)^(+)/CD_(8)^(+)平衡、调节Th17/Treg平衡)的调控作用,对中医药调控CHB免疫功能展开综述。
Chronic hepatitis B is a liver disease caused by hepatitis B virus infection with immune dysfunction as the main mechanism.It requires synergistic treatment with antiviral and immune regulation to clear infected hepatocytes and establish long-term control of viral.Modern medical research shows that HBV immune tolerance is associated with immunosuppression and is closely related to the concept of healthy Qi deficiency in TCM.The regulatory effects of traditional Chinese medicine on chronic hepatitis B innate immunity(including NK cells,dendritic cells and liver macrophages)and adaptive immunity(regulating Th1/Th2 balance,CD_(4)^(+)/CD_(8)^(+)balanceand Th17/Treg balance)were reviewed.
作者
陈博武
高月求
CHEN Bowu;GAO Yueqiu(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《辽宁中医杂志》
CAS
2021年第4期210-214,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81673938,81673935,81774256,81874436)
国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(2018ZX10725504)
上海市中医药事业发展三年行动计划(ZY(2018-2020)-CCCX-2003-01)
上海市中医专科(专病)联盟建设项目[ZY(2018-2020)-FWTX-4001]
重大疑难疾病中西医临床协作试点项目[ZY(2018-2020)-FXTW-2004]。
关键词
慢性乙型肝炎
免疫调节
中医药
研究进展
chronic hepatitis B
immuneregulation
traditional Chinese medicine
research progress
