摘要
通过对２４７８例等待肾脏移植受者的ＨＬＡ体液致敏状态的观察，进行移植受者群体反应性抗体（ＰＲＡ）的研究及其与肾脏移植的关联。结果显示，ＰＲＡ是移植前受者是否致敏的指标，与淋巴细胞毒（ＣＤＣ）的不相合呈正相关，ＰＲＡ≥３０．００％的受者接受ＣＤＣ阴性移植肾仍然全部发生超急排斥，而ＰＲＡ阴性受者仅为１２．４６％。因此，ＰＲＡ分析对辨别ＨＬＡ基因的免疫状态和预测超急排斥反应以及改善肾脏移植的效果具有普遍意义。
Studied panel active antibody(PRA) in renal transplant recipients and the correlation between PRA and renal transplantation by observating HLA humoral sensitization in 2 478 recipients awaiting for renal transplantation. The results suggested that PRA was an indicator of presensitization in recipients before transplantation, and PRA correlates positively with CDC incompatibility. It was also showed that 10000% recipients with PRA≥3000% experienced hyperacute allograft rejection, although these recipients were given renal allograft with negative CDC. By comparison, only 12.46% recipients with negative PRA developed hyperacute rejection of renal allograft. Therefore, an analysis of PRA played an important role in differentiating the immunity of HLA genes, predicting hyperacute allograft rejection, as well as in increasing success of renal transplantation.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1998年第2期137-139,共3页
Chinese Journal of Immunology
基金
国家卫生部科研基金
