摘要
２１例维持性血液透析（ＭＨＤ）病人，在透析治疗的同时，加用黄芪注射液治疗，３个月后患者的免疫功能获得明显改善。与正常人相比，ＭＨＤ患者外周血ＣＤ８Ｔ细胞、血清ｓＩＬ－２Ｒ水平、血清ＴＮＦ含量均明显升高；而外周血中ＣＤ４／ＣＤ８比值和淋巴细胞ｍＩＬ－２Ｒ阳性细胞数明显下降，显示ＭＨＤ患者的细胞免疫功能降低。经黄芪注射液治疗３个月后，患者外周血ＣＤ４Ｔ细胞、ＣＤ４／ＣＤ８比值明显升高，ＣＤ８Ｔ细胞下降至正常人水平，ＣＤ４／ＣＤ８比值上升到正常水平。治疗后患者血清ｓＩＬ－２Ｒ和血清ＴＮＦ含量较治疗前明显降低，外周血ｍＩＬ－２Ｒ和ＬＦＡ－１阳性淋巴细胞也有一定增加。结果显示黄芪有显著改善ＭＨＤ患者细胞免疫功能的作用。
The immunological functions of twentyone patients with maintained hemodialysis(MHD) treated with Astragalus Membranaceus during routine hemodialysis were investigated. Comparing with normal subjects, the percentage of CD8 positive cells, serum levels of sIL2R and TNF of patients with MHD were higher(P<001,P<0001) while the CD4/CD8 ratio and the expresion of mIL2R on peripheral blood lymphocytes were lower(P<001,P<001), but the expression of LFA1 on peripheral blood lymphocytes was normal. After treatment with Astragalus Membanaceus, the percentage of CD4 positive cells and the CD4/CD8 ratio were higher(P<005,P<005) while the serum levels of sIL2R and TNF were lower(P<0001,P<001) than those before treatment. The percentage of CD8 positive cells and the CD4/CD8 ratio recovered to normal levels. The results showed that Astragalus membranaceus was able to regulate beneficially the imbalanced cellular immunological functions of patients with MHD.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1998年第2期129-131,共3页
Chinese Journal of Immunology
关键词
黄芪
维持性
血液透析
细胞免疫功能
Astragalus membranaceus Maintained hemodialysis Cellular immunological functions
