摘要
以蒙药药材荜茇为原料,经过分离、纯化得胡椒碱,进一步水解得胡椒酸.以胡椒酸和丁二醇为原料合成了胡椒酸丁二醇单酯,经13CNMR、1HNMR、UV、IR、EA表征后确证结构并做了一般药理实验,实验结果表明目标化合物具有良好的降血脂活性.
Piperic acid was obtained by hydrolyzing Piperine that was extracted from seeds of Piper Longum L （Traditional medicine of Mongolian）. Using Piperic acid and butanediol as the raw materials to synthesize butanediol piperic monoester,and then the title compound was identified by the HPLC,^13 CNMR,^1 HNMR, UV, IR spectrum and elemental analysis. Pharmacological experiments showed that this compound had high anti-hyperlipidemia activity.
出处
《内蒙古大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第1期52-55,共4页
Journal of Inner Mongolia University：Natural Science Edition
基金
国家自然科学资助项目(No.30160103)
关键词
荜茇
降血脂作用
胡椒酸酯
胡椒碱
Piper longum L
anti-hyperlipidemia
Piperic ester
Piperine
