摘要
目的比较听觉诱发电位指数和双频指数监测计算的血浆-效应室平衡速率常数(ke0)应用于控制效应位浓度输注系统对血流动力学的影响,以评价其临床应用的安全性。方法85例不用术前药的患者分为TP组(39例)、TE1组(23例)和TE2组(23例),TP组靶控血浆浓度,TE1组和TE2组分别应用ke0=0.62/min和1.83/min的靶控效应室浓度,记录血压、心率和患者意识消失的时间。结果TP组的意识消失的时间为75s,显著长于TE1和TE2组的40s(P值均<0.05)。3组间收缩压降低的最大幅度、达到最大降幅的时间以及心率变化的差异均无统计学意义(P值均>0.05)。结论相对于靶控血浆浓度,靶控效应室浓度缩短了达到意识消失的时间,同时不会增加血压降低的幅度。
Objective To compare the effects of target-controlled plasma concentration and effect-site concentrations （2 ke0s） of propofol on hemodynamics in Chinese patients. Methods Eighty-five patients were divided to 3 groups.. TP （TCI device controlled the plasma concentration, n = 39）, TE1 and TE2 groups （TCI device controlled the effect-site concentration with the values of ke0 0.62/rain, and 1.83/min, respectively, n= 23 each）. Blood pressure, heart rate and the time of loss of consciousness （LOC） were an recorded. Results The time of LOC was significantly longer in TP group （75 s） than those in the TEl and TE2 groups （40 s and 40 s, P〈 0.05）. The maximum amplitude of hypotension, the time to the lowest blood pressure, and the change of heart rate were similar among 3 groups （all P〉 0.05）. Conclusion Target-controlled effect-site concentration of propofol can shorten the time of unconsciousness and has no negative effect on patients hemodymamics compared with target-controlled plasma concentration of propofol.
出处
《上海医学》
CAS
CSCD
北大核心
2009年第1期43-45,共3页
Shanghai Medical Journal
关键词
麻醉药
丙泊酚
药效动力学
血浆-效应室平衡速率常数
Anaesthetics
Propofol
Pharmacodynamic
Plasma effect site equilibration rate constant
