摘要
目的确定术前用药和年龄对50％患者意识消失所需要的靶控丙泊酚浓度（CP50）的影响。方法156例ASAⅠ～Ⅱ级患者随机分为有术前用药组（n=72）和无术前用药组（n=84），每组再均分为18～39岁、40～59岁和60～85岁三个年龄亚组，患者随机接受预先设定的靶控丙泊酚浓度，以镇静／警觉评分（0AA／S）评估镇静程度，OAA／S≤3分认为意识消失。结果有术前用药组和无术前用药组CP50和95％患者意识消失的靶控浓度（CP95）分别为2．02、3．47和2．38、4．20μg／ml（P〈0．05）；术前用药轻度降低18～39岁组的CP50而CP95显著降低（P〈0．05），40～59岁组CP50和CP95均显著降低（P〈0．05），60～85岁组CP50显著降低（P〈0．05）但CP95仅轻度降低。除无术前用药组18～39岁和40～59岁亚组间CP50差异无显著意义，年龄亚组间CP50和CP95差异均有显著意义（P〈0．01）。结论年龄和术前用药均是影响丙？白酚靶控输注药效学的显著因子。
Objective To study the effect of premedication and age on CP50 of propofol targetcontrolled concentration. Methods One hundred and fifty-six patients ASA Ⅰ-Ⅱ were divided into premedication group and non-premedication group. According to age,each group was divided into subgroups 18-39 yr, 40-59 yr and 60-85 yr. Each patient randomizelly received preestablished propofol target-concentration, which was maintained for at least 8 rain. Sedation level was evaluated with OAA/S. OAA/S≤3 was defined as unconsciousness. Results CP50 and CP95 were 2.02μg/ml, 3.47 μg/ml and 2.38μg/ml, 4.20μ/ml in group premedication and non-premedication, respectively （P〈 0.05）. CP50 and CP95 decreased significantly in premedication group （P〈0.05） except for CP50 in subgroups 18-39 yr and CP95 in subgroup 60-85 yr. CP50 and CP95 had significant difference between age groups （P〈0.05） except for CP50 between subgroups 18-39 yr and 40-65 yr in non-premedication group. Conclusion Premedication and age are the factors highly influencing on propofol pharmacodynamics.
出处
《临床麻醉学杂志》
CAS
CSCD
2006年第7期499-501,共3页
Journal of Clinical Anesthesiology
关键词
药效学
丙泊酚
药物输注系统
Pharmacodynamics
Propofol
Drug delivery system
