摘要
以氰基丙烯酸正丁酯为载体，用乳化聚合法制备了万乃洛韦聚氰基丙烯酸正丁酸毫微粒，通过单因素试验法初选，均匀设计法精选，确定了较佳处方和制备工艺，按此条件制备的产品外观为白色胶体溶液，粒径１０５±３３ｍｍ，包封率８４．８５％，载药量１１．２０％．
VACV-PBCA-NP was prepared by emulsion polymerization method with the polybutyl- cyanoacrylate. An optimal condition was established by single factor test and uniform design test. Under this optimul condition, a white colloidal solution can be prepared in which drug loading was 11.20%, drug embledding ratio was 84. 85%. average diameter of the nanoparticles was 105±33nm.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1998年第1期14-16,共3页
West China Journal of Pharmaceutical Sciences
基金
国家自然科学基金
