摘要
本文报道了可生物降解的ＰＥＬＡ微球的优化工艺，制得平均球径为３２．５μｍ，平均包封率为７５％以上，临界相对湿度约７８％以及流动性好的白色球形粉末。体外释放药物符合零级释放规律，达到了肌内注射用的缓释微球的要求。
Preparation of biodegradable PELA microspheres and optimization of the technology are reported.Globular powder with good fluidity was obtained with the mean diameter of 32.5 μm,rate of encapsulation over 75% and critical relative humidity(CRH) about 78% In vitro,the LNG release of the LNG microspheres was found to beofzero order,The aim of the microspheres prepared as an intramuscular injection with sustained release action was proved to be achieved.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1994年第4期215-217,共3页
West China Journal of Pharmaceutical Sciences
基金
国家计划生育委员会资助
关键词
聚乳酸
聚乙二醇
嵌段共聚物
微球
优化工艺
Poly(D,L-lactide)-poly(ethylene glycol) block copolymer Mi crospheres Sustained release system Levonorgestrel(LNG) Solvent-volatilization method financially supborted by the National Commi ttee for Family Planning(Master degree post-graduate)
