摘要
根据β－环糊精与秦皮甲素乙素形成包含物，发生荧光增敏作用的原理，在适当的条件下，对兔血浆中的秦皮甲素乙素进行定时监测，绘制药时曲线，按照实用药代动力学的系列公式计算药代动力学参数，其几个主要药动学参数分别为：秦皮甲素的消除半衰期ｔ_１／２（β）为９．８１ｈ，吸收半衰期ｔ_１／２（ｋａ）为０．４５ ｈ，秦皮乙素的消除半衰期ｔ_１／２（β）为１２．２１ｈ吸收半衰期ｔ１／２（ｋａ）为０．３３ ｈ，曲线下面积秦皮甲素ＡＵＣ为１８．３３μｇ·ｈ·ｍＬ~－１，秦皮乙素ＡＵＣ为２７．１μｇ·ｈ·ｍＬ~－１，二者的吸收代谢虽不相同，但无显著差异．
Our study was based on β-cyclodextvin and aesculin and aesculetine to form micella respectively, and to improve sensitivity of fluorometry. Under proper experimental conditions. We monitored the content of aesculin and aesculetine in the rabbit plasmain time and drew drug-time curves. According to a series of practical practical pharmacokknetics formulate for calculation,we obtained pharmacokinetics parameters as follows. The eliminate half-life time of aesculin t_1/2(β) was 9.81 h. The absorption half-life time of aesculin t_1/2(Ka) was 0.45 h. The eliminate half-life time of aesculetine t_1/2(β) was 12.21 h. The absorption half-life time of aesculetine t_1/2(Ka) was 0.33 h.The area under the curve of aesculin and aesculetine was 18.33μg·h·mL^-1 and 27.1μg·h·mL^-1 ,respectively. Although there were some differences in absorption and excreton between them, there was no significant difference.
出处
《沈阳药科大学学报》
CAS
CSCD
1998年第1期3-7,共5页
Journal of Shenyang Pharmaceutical University
