摘要
为了研究丹皮酚的药物代谢动力学,采用高灵敏的偶合反应化学发光法,对兔血中的血药浓度进行监测,在pH为9.2的介质中,以H_2O_2氧化丹皮酚的反应与Luminol-H_2O_2-CO^(2-)化学发光反应相偶合,测得牡丹皮和徐长卿中丹皮酚在兔体内的吸收速率分别为2.07和0.499h^(-1),消除半衰期分别为11.76和3.04h。相对而言牡丹皮所含丹皮酚具有吸收快、消除慢、生物利用度大的优点。
In order to study paeonol pharmacokinetics, we monitor blood drug concentration by highly sensitive chemiluminescence with coupled reaction. In a medium at pH 9.2. we coupled H2O2 oxidizing paeonol with Luminol-H2O2-Co2- chemiluminescent reaction. We determined that paeonol in Cortex Moutan and Radix Cynanchi Paniculati absorption rate is 2. 07 and 0. 499 h-1.elimination half-life time is 11. 76 and 3. 04 h. respectively. Paeonol in Cortex Moutan relatively possesses faster absorption, slower elimination and larger bioavailability.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
1993年第12期1417-1419,共3页
Chinese Journal of Analytical Chemistry
关键词
偶合反应
化学发光
药物
丹皮酚
Coupled reaction ,Chemiluminescence,Pharmacokinetics.
