摘要
目的观察A型肉毒毒素治疗带状疱疹后神经痛的临床疗效和不良反应。方法重度带状疱疹后神经痛患者29例,应用A型肉毒毒素进行皮内注射治疗,问卷调查记录每例带状疱疹后神经痛患者治疗前、治疗后1,2,4,8周带状疱疹后神经痛疼痛严重程度,观察不良反应。结果A型肉毒毒素治疗后1周,带状疱疹后神经痛疼痛严重程度均较治疗前明显下降(P<0.01),疗效可至少维持8周,且不良反应轻微、短暂。结论A型肉毒毒素皮内注射治疗带状疱疹后神经痛临床疗效显著,不良反应轻微、短暂,值得临床研究。
Objective To evaluate the efficacy and advers（reactions of botulinum toxin type A used for postherpetic neuralgia （PHN） . Methods Twenty nine adult patients with severe postherpetic neuralgia were enrolled in a 8 week open study, botulinum toxin type A was injected into multiple sites intradermally. At pre-administration and one, two, four, and eight weeks after administration, all the patients wrote daily diaries recording pain symptom improvement and the occurrence of treatment-related adverse reactions. Results After 1-week treatment with botulinum toxin type A, all the patients showed significant reduction of pain symptom and maintenance at least 8 weeks （ P〈0. 01） . No severe adverse reactions were observed. Conclusion Intradermal injection of botulinum toxin type A is a safe and effective method for severe postherpetic neuralgia.
出处
《实用疼痛学杂志》
2008年第5期326-328,共3页
Pain Clinic Journal
基金
江苏省科技厅资助项目(No.BS2006016)
