摘要
目的观察A型肉毒毒素治疗带状疱疹后顽固性神经痛的效果。方法将40例带状疱疹后顽固性神经痛患者随机分为治疗组和对照组各20例,两组均排除其他因素引起的疼痛,均给予抗病毒、营养神经、对症治疗,治疗组给予A型肉毒毒素沿神经走向行全身多点皮下注射,每点注射0.1mL(含2.5万U)。结果治疗第1天治疗组疼痛积分为(6.9±0.85)分,对照组疼痛积分为(7.8±0.7)分,两组比较差异无显著性;治疗第3,第7,第14和第30天,治疗组疼痛积分均较对照组明显下降,且均差异有显著性(均P<0.05)。结论沿神经走向皮下注射A型肉毒毒素可有效治疗带状疱疹后顽固性神经痛,改善患者的精神、食欲和睡眠状态。
Objective To study the effect of botulinum toxin A on refractory postherpetic neuralgia.Methods 40 patients with herpes zoster neuralgia,excluded other pain causes,were randomly divided into treatment group and control group,20 cases in each group.All 40 patients were treated with antivirus,nutrition,symptomatic.The patients in the treatment group was treated with botox A along nerve,and the injection volume was 0.1 mL containing 25,000 units every point.Results There＇s no difference （P0.05） between treatment group and control group after being treated 1 day for the pain points,which was 6.9±0.85 and 7.8±0.7,respectively.After treated for 3 days,7 days,14 days and 30 days,the pain scores of treatment group decreased significantly,and the differences between treatment group and control was significant as well（P0.05 for all）.Conclusion The injection of botox A along nerve can cure herpes zoster neuralgia,and improve the energy,appetite and sleep of the patients efficiently.
出处
《医药导报》
CAS
2010年第11期1452-1453,共2页
Herald of Medicine
