摘要
采用Ｏ１１１Ｂ４大肠杆菌腹腔注射的方法诱发大鼠实验性腹膜炎，按Ｌ８（２７）正交设计法观察腑安冲剂及其组分对实验性腹膜炎大鼠内毒素血症的影响及对肺脏的保护作用。结果显示：腑安冲剂及其组分能降低外周血内毒素、肿瘤坏死因子及肺组织丙二醛的含量，并有增加肺组织谷胱甘肽含量及降低肺系数、肺灌洗液中蛋白含量及白细胞数等显著作用。经多指标同步分析表明：用腑安冲剂治疗腹膜炎、内毒素血症及减轻肺损伤以全方为最佳组方，从而进一步论证了用药处方的合理性与科学性。
The Protective action of Fuan disperser and its components against endotoxemia and lung injury were investigated and compared in experimental peritonitis with L 8(2 7)orthogonal design.The peritonitis was induced by injecting E Colio 111 B 4 intraperitonealy. Results showed that administration of Fuan disperser or its components could reduce the extent of endotoxemia and TNF of rat′s periphery blood and alleviate the pulmonary injury with the obvious action of reducing the content of MDA in rat pulmonary homogenate,of increasing the pulmonary level of GSH,and of reducing the protein content in bronchial alveolar lavage liquid as well as the lung coefficient.Fuan disperser had a strong effect against endotoxemia and had a protective effect on lung injury during experimental peritonitis.It was suggested that Fuan disperser was the best combination of its components.
出处
《中国中西医结合外科杂志》
CAS
1997年第2期76-78,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
