摘要
采用大鼠肝缺血再灌注损伤模型，放免法检测缺血后、缺血再灌注２小时和缺血再灌注２４小时３个时限肝组织血栓素Ｂ２与６－酮－前列腺素Ｆ１α含量，并作血清酶测定、光镜及电镜检查，探讨血栓素Ａ２、前列环素在肝缺血再灌注损伤中的作用及中药制剂川芎嗪的影响。结果：肝缺血再灌注时肝组织血栓素Ｂ２含量明显升高（Ｐ＜０．０５），以再灌注早期为著（Ｐ＜０．０１），６－酮－前列腺素Ｆ１α含量虽也升高，但差异无显著性（Ｐ＞０．０５）。应用川芎嗪后缺血肝组织血栓素Ｂ２含量明显降低（Ｐ＜０．０５），病理损伤亦较轻。提示：血栓素Ａ２、前列环素这对微循环调节因子的代谢失衡是参与肝缺血再灌注损伤发生的重要因素之一，川芎嗪可对抗血栓素Ａ２的合成与活性，从而减轻肝缺血再灌注损伤。
he changes of thromboxane and peostacyclin in liver thissue and the protive effect of YMP on ischemia/reperfusion liver injury were studied by using a 120-minute warm ischemia/reperfusion rat model.Serum enxyme levels and the amount of hepatic thromboxane B were significantly icnreased during liver ischemua/reperfusion.The increment was significantly inhibited by TMP treatment.Liver pathology by ligh and electromicroscopy was shown inproved,much more promounced in the treated groups.It was suggested that the injury was due,in part,to hepatic microcirculatory failure.TMP has protectice effect against it in rats though inhibiting suynthesis of thromboxane and maintaining the balance between thromboxane and prostacyclin。
出处
《中国中西医结合外科杂志》
CAS
1997年第6期393-395,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
肝缺血
血栓素A2
前列环素
川芎嗪
再灌注损伤
liver ischemia/reperfusion
thromboxane
prostacyclin
liver injury
tetramethypyraxine
