摘要
三七总皂甙对大鼠肝缺血再灌注损伤的保护梁力建１何强２吕明德１彭宝冈１黄洁夫Ｔｈｅｐｒｏｔｅｃｔｉｖｅｅｆｅｃｔｓｏｆｐａｎａｘｎｏｔｏｇｉｎｓｅｎｇｏｎｌｉｖｅｒｉｓｃｈｅｍｉａ－ｒｅｐｅｒｆｕｓｉｏｎｉｎｊｕｒｙｉｎｒａｔｓＬＩＡＮＧＬｉ＿Ｊｉ...
AIM To study the protective effects of panax notoginseng saponins(PNGS) compared with verapamil in a partial hepatic ischemic animal model. METHODS Twenty_four male SD rats with body weight of 300g～350g were divided into four groups ( n =6), and Asakawa's method was used to create hepatic ischemia model in them. Normal saline was administered in simple hepatectomy group and control group, while the other two groups were given verapamil (1 25mg/kg) and PNGS (50mg/kg) 5 minutes before ischemia. The survival rates, liver function tests, histologic examination and MDA and SOD test 90 minutes after ischemia were recorded respectively. RESULTS Both PNGS and verapamil had protective effects on ischemia-reperfusion injury in the rats and PNGS had better action than verapamil in raising survival rates (63 3%, 36 0% after 120 min, P <0 05), lowering ALT (2118±430, 3401±592, P <0 01), decreasing hepatic cell necrosis (5%～25%, 20%～40%), or enhancing SOD activity (149±14, 125±16, P <0 05). CONCLUSION PNGS can provide effective protection against liver ischemia-reperfusion injury.
