摘要
本实验以１２５Ｉ－ＬＰＳ对大鼠灌胃后，观察腹膜炎大鼠肠源性内毒素移位后各脏器中分布。结果表明：急性感染性腹膜炎可致肠源性内毒素移位增加，各重要脏器中均含不同浓度的内毒素，内毒素含量由高至低为：肾、肺、肝、胰、肠系膜淋巴结、心脏（Ｐ＜０．０５）。大承气汤能明显抑制腹膜炎大鼠肠源性内毒素移位（Ｐ＜０．０１），并可增加１２５Ｉ－ＬＰＳ的粪便排出量（Ｐ＜０．０１）。为临床治疗肠源性内毒素血症提供了一个可靠的方法。
fter125I-LPS was poured down into the stomach of rats in the expeiment,the distribution of enterogenic endotoxin in rats with peritonitis was surveyed.The results indicated that acute infectious peritonitis could promote the translocation of intestinal endotoxinThe amounts of endotoxin in different oragans were differentThe order from high to low is in the kindey,liver,lung,pancreas,spleen,mesenteric lymph node and heart(P<005)DaChengqi Tang could significantly inhibit the translocation of enterogenic endotoxin in rats with peritonitis(P<001),and increase the amount of 125I-LPS in tacces (P<001)Thus this herbal decoction might be an effective method to be evacuated in the treatment of enterogenic endotoxemia
出处
《中国中西医结合外科杂志》
CAS
1997年第6期374-377,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
内毒素移位
大承气汤
腹膜炎
内毒素血症
translocation of enterogenic endotoxin,Dachengqi Tang,peritonitis
