摘要
采用立体定向技术，应用射频毁损深部位肿瘤。我们应用射频治疗仪在不同温度，不同时间下对蛋清、犬脑组织和人脑胶质细胞瘤进行毁损试验，并对毁损后的犬脑组织和人脑胶质细胞瘤进行光镜及电镜观察。发现４２℃、１２０Ｓ时可产生人脑胶质瘤的不可逆损伤，损伤区与未损伤区在光镜下观察界限非常明确，且随温度和时间的变化而变化。进行统计学分析，应用回归分析和目标归划方法，得到肿瘤的受损范围与射频毁损所采用的最适温度和时间的对应关系的数学模型。射频毁损灶的大小与温度的相关性强，与时间的相关性弱。据此研究短时间、高热毁损较为适宜，重要结构区、范围小的病灶可以适当延长时间（不宜超过３分钟）和用相对较低的温度加热。
おe are planning to cure this kind of disease by using radiofrequency (RF) capacitive hyperthermia and stereotaxic technique. According to the principle and specific property of RF heating inductively, we analysed the influence factors of RF heating and found that there are obvious differentials on heating time and temperature among different reports. There are no experimental foundation of precise relationship between heating temperature、time and the desired lesion size extent.We applicate RF heat egg white、dog brain and human brain astrocytoma in different temperature and different time. Pathology and ultrastructural organizition indicate: the incovertible lesion of human brain astrocytoma occurred in 42℃、120s. Pathology testified that there are definate demarcation line between the lesion region and non-lesion regions and vary with the variance of action temperature and time. Based on these tests, this article give a method of appling regression analysis and goal programming, according to the date pattern of the relationship between the lesion ranges and the optimum temperature and time of RF treatment on different tissues. We suggest to apply the best heating temperature and time on the types and the ranges of disease tissues. Stimulitanously, we found the lesion ranges of RF correlate highly to temperature and lowly to action time, this situation is especially obvious in human brain astracytoma, the influrence of actiontime is only one-fifth as the temperature. As a result, we think that RF heating in short time、high temperture is suitable, however, heating important region、narrow ranges disease, we can properly prolong the time (not beyond 3 minutes) and use relative lower temperaature. This article give a more scientific and precisier method on the usage of RF.
