摘要
[目的]观察加味四君子汤联合甲硝唑、叶酸三联疗法对脾虚血瘀型萎缩性胃炎癌前病变患者环氧合酶-2（COX-2）蛋白表达的影响及胃黏膜病理改变。[方法]68例脾虚血瘀型萎缩性胃炎和（或）伴有肠上皮化生（IM）及异型增生（Dys）患者均服用甲硝唑与叶酸,其中三联组34例同时服用加味四君子汤,甲硝唑服用1周,其他服用至第24周,用ABC免疫组化法检测COX-2蛋白。观察比较治疗前后COX-2蛋白表达及黏膜病理改变。[结果]三联组治疗后COX-2蛋白表达较对照组减弱（P〈0.01）,病理改变逆转优于对照组（P〈0.05-0.01）。[结论]脾虚血瘀与萎缩性胃炎癌前病变关系密切。中西医结合疗法能改善症状,一定程度逆转胃黏膜萎缩I、M和Dys,并降低COX-2蛋白表达。
[Objective]To study the curative effects of symptom, mucosal changes, expression of COX-2 in chronic atrophic gastritis（CAG） and gastric precancerous lesion（GPL） differentiated as spleen deficiency and blood stasis by therapy of integrated TCM and western medicine. [Methods]Sixty eight patients, diagnosed as CAG and GPL with gastroendoscopy and pathological examination, differentiated as spleen deficiency and blood stasis were randomly divided into treatment group （n=34）, received Jiawei Sijunzi decoction ＋ Metronidazole ＋ folic acid, and control group （n=34）, received Metronidazole ＋folic acid only. Metronidazole was given for one week, the others were 24 weeks. The symptoms of the patients, mucosal pathological changes and the expression of COX-2 were observed before and after treatment. [Results]The curative effects of symptom, mucosal pathological changes in treatment group were significantly improved compared with that in control group（P〈0. 05-0. 01）. The expression of COX-2 in treatment group was significantly lower compared with that in control group（P〈0. 05）. [Condusion]Spleen deficiency and blood stasis plays an important role in pathogenesis of CAG and GPL, integrated TCM and western medicine can decrease the expression verse the pathological changes to some extent. of COX-2, improve the clinical symptom and reverse the pathological changes to some extent.
出处
《中国中西医结合消化杂志》
CAS
2008年第5期289-291,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
辽宁省自然科学基金项目(20052070)
关键词
胃炎
萎缩性
癌前病变
中西医结合
环氧合酶-2
atrophic gastritis
precancerous lesion
therapy of integrated TCM and western medicine
COX-2
