摘要
病证结合的临床研究模式是当前中医临床治疗和研究最重要的模式之一。慢性胃炎中医证候内在物质基础涉及胃镜下胃黏膜表现、病理组织学、幽门螺旋杆菌(Hp)感染、炎性介质、胃肠激素、代谢、免疫、内分泌以及离子通道等多方面内容,具有多样性和复杂性的特点。系统生物学研究方法和数学建模联合实验方法验证为慢性胃炎中医证候物质基础研究提供了新的思路。同时中医证候的时空性、系统性及多层次性决定了慢性胃炎不同证候内在物质基础的复杂性,提示在研究方法和理念上需要进一步思考研究过程中遇到的核心问题。
The mode of combination disease and syndrome is currently one of the most important modes of clinical treatment and research of TCM. The pathological basis of TCM syndrome of chronic gastritis has diversity and complexity. It involves endoscopic performance, gastric mucosal pathology, Hp infection, inflammation regulatory pathways, gastrointestinal hormones, absorption, energy metabolism, immune, endocrine and ion channels, and many other contents. Systems biology research methods and mathematical modeling combined with experiments provide a new way for the pathological basis of chronic gastritis. The time-space characteristic, systematic and hierarchical of TCM syndromes caused the complexity of the pathological basis of chronic gastritis. Those problems need further reflection on research methods and philosophy.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2016年第7期2482-2486,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.91129714)
教育部高等学校博士学科点专项科研基金项目(No.20120013110014)~~
关键词
慢性胃炎
病证结合
中医证候
物质基础
Chronic gastritis
Combination of disease and syndrome
TCM syndrome
Pathological basis
