摘要
[目的]研究湖北海棠的毒性。[方法]小鼠急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验、大鼠30 d喂养试验。[结果]湖北海棠属实际无毒物质;Ames试验、微核试验和精子畸形试验结果均为阴性;大鼠30 d喂养试验结果显示该样品30 d喂养对大鼠各项观察指标未见毒性作用。[结论]在本次实验条件下,湖北海棠为无毒物质,未显示有遗传毒性和亚急性毒性作用。
[Objective]To study the toxicity of Malus hupehensis. [Methods]Acute toxicity test in mice,Ames test,micronucleus test of bone marrow PCE cell in mice, sperm shape abnormality test in mice, thirty-day-feeding study were conducted. [Results]Malus hupehensis was a substance with no toxicity. The results of genetic toxicity test were all negative, including Ames test,micronucleus test and sperm shape abnormality test. The result of thirty- day- feeding study was also negative. [Conclusion]Malus hupehensis is a substance with no acute toxicity and no genetic toxicity and sub-acute toxicity in this test.
出处
《预防医学论坛》
2008年第11期1004-1008,共5页
Preventive Medicine Tribune
