摘要
目的观察甘蔗渣多糖对免疫抑制小鼠免疫功能的影响。方法采用环磷酰胺(CY)造模法复制小鼠免疫抑制模型,测定甘草渣多糖对实验动物免疫器官重量指数、腹腔巨噬细胞的吞噬功能、迟发型变态反应(DTH)、溶血素(IgM)含量、溶血空斑形成、T细胞百分比和淋巴细胞转化。结果小鼠灌胃剂量为200、400mg/(kg·d)的甘蔗渣多糖能显著提高免疫器官重量,增强小鼠巨噬细胞的吞噬功能,提高DTH和促进IgM、溶血空斑形成并且增加T细胞百分比和淋巴细胞转化率。结论甘蔗渣多糖有显著提高免疫抑制小鼠免疫功能的作用。
Objective To observe the effects of bagasse polysaccharide on the immune functions ofimmunosuppressed mice. Methods Immunosuppressed mouse models were established by intraperitoneal injections with cyclophosphamide followed by daily intragastric administration of bagasse polysaccharide. After the treatments, the mice were examined for immune organ weight index, phagocytotic function of the macrophages, delayed type hypersensitivity, serum IgM level following exposure to chicken red blood cells, formation of hemolytic plaques, T cell percentage and lymphocyte transformation. Results Treatment of the immunosuppressed mice with bagasse polysaccharide at the daily dose of 200 and 400 mg/kg significantly increased the weight of the immune organs, phagocytotic function of the macrophages, delayed type hypersensitivity, serum IgM level against chicken red blood cells, formation of hemolytic plaques, T cell percentage and lymphocyte transformation. Conclusion Bagasse polysaccharide can enhance the immune functions of immunosuppressed mice.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2008年第10期1911-1913,共3页
Journal of Southern Medical University
关键词
甘蔗渣多糖
环磷酰胺
免疫功能
bagasse polysaccharide
cyclophosphamide
immune functions
