摘要
目的：探讨儿童多发性抽动症的发病机制。方法：用荧光法和生化法测定患者血液多巴胺等单胺类神经递质的含量及钠钾ATP酶活性的变化。结果：多发性抽动症组多巴胺和去甲肾上腺素含量、钠钾ATP酶活性和5-羟色胺的转换率均显著高于正常对照组（P＜0．01）。结论：儿童多发性抽动症患者儿茶酚胺（主要是多巴胺）含量的高水平、5-羟色胺转换率的增高以及钠钾ATP酶活性的改变可能是多发性抽动症的发病机制之一。
Aim:to explore the neurobiochemistry mechanisms of childhood Tourette syndrome. Methods:using the flrorescence tests and biochemistry techniques to examine the contents of monoanine neurotransmitters such as dopanine etc. and the activity change of sodium-potassium ATP enzyme in patient's blood. Results: All of the contents of dopamine and noradrenalin,the activety of sodium-potassium ATP enzyme,and the transversing ne of 5-hydroxyptamine in patients with childhood Tourette syndrome are apparenths higher than those in control group (P<0. 01～0.0001). Conclusions:The high level of the contents of catecholamines(including dopamine manihs). the rise of transversing rate of 5-hydroxytryptamine,and the activity change of sodium potassium ATP enzyme may be one portion of the pathogenic mechanisms about the childhood Tourette syndrome.
出处
《临沂医学专科学校学报》
1997年第4期253-255,共3页
Journal of Linyi Medical College
