摘要
对L-丙氨酸甲酯(L-AlaMe)消旋方法进行改进,研究了消旋制备DL-丙氨酸甲酯的条件。结果表明:当以水杨醛为催化剂、强酸性D072离子交换树脂为助催化剂、n(C7H6O2):n(L-AlaMe·HCl)=0.1回流反应时,消旋效果最好。该法可减少环境污染、节约能耗、降低成本,也可拓展到其他旋光性氨基酸酯的消旋反应中去。
The racemization method of L-alanine methyl ester was improved and the reaction conditions for the racemization of dl-alanine methyl ester were studied in this paper. The experiment results indicated that a higher yield of l-alanine methyl ester could be obtained when salicylaldehyde,strong acid D072 ion-exchange resin are used as the auxiliary catalysts,and n(C7H6O2):n(L-alanine methyl ester)=0.1 at reflux. This method could reduce environmental pollution,save energy consumption and reduce cost,and it can also be extended into the racemization of other optical amino acid esters.
出处
《化工生产与技术》
CAS
2008年第5期30-33,共4页
Chemical Production and Technology
关键词
DL-丙氨酸甲酯
消旋
催化
D-丙氨酸
水杨醛
dl-alanine methyl ester
racemization
catalyze
salicylaldehyde
salicylaldehyde
