摘要
目的探讨四甲基偶氮唑盐法(MTT)体外药敏试验指导老年胰腺癌化疗的价值。方法46例老年胰腺癌患者,21例存化疗前采用MTT法进行体外药敏试验,其中MTT敏感组15例、不敏感组6例,根据药敏结果指导化疗。对照组25例则按常规化疗。结果比较MTT药敏试验组与对照组的生存率,P=0.01,差异有统计学意义。比较药物敏感组与对照组的生存率,P=0.008,差异有统计学意义。结论MTT法体外药敏试验指导老年胰腺癌化疗是可行的,疗效也是满意的。
Objective To study the therapeutic effect of MTT chemosensitivity-guided chemotherapy on pancreatic tumors in elderly patients. Methods 46 elderly patients with pancreatic carcinoma were randomized to the study group （n=21） and the control group （n=25）. In vitro chemosensitivity test was performed by MTT before chemotherapy in the 21 patients of the study group. As a result, 15 patients were included in the MTT sensitive group and the remaining 6 patients in the MTT non sensitive group. Based on the MTT results, individualized chemotherapy was administered. The 25 patients in the control group received routine chemotherapy. Results There was statistically significant difference in the survival rate between the study control groups as a whole, and between the MTT sensitive group and the control group （P=0.008）. Conclusions MTT chemosensitivity test is directive in guiding chemotherapy for pancreatic carcinoma in elderly patients with pancreatic carcinoma, and the therapeutic outcome is satisfactory.
出处
《老年医学与保健》
CAS
2008年第5期267-269,共3页
Geriatrics & Health Care
基金
上海市科委重点项目:药敏指导化疗对胆
胰肿瘤疗效及多药耐药关系的探讨(编号:044119629)
关键词
老年人
胰腺肿瘤
比色法
药物筛选试验
抗肿瘤
Aged
Pancreatic neoplasms
Colorimetry
Drug screening assays, antitumor
