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二甲双胍对肥胖葡萄糖耐量降低患者血管内皮功能的影响 被引量:6

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摘要 42例成人肥胖(BMI〉25kg/m^2)葡萄糖耐量减低(IGT)患者服用二甲双胍0.25-0.5g,3次/d,共24周。采用高频超声测试肱动脉内皮舒张功能变化。结果治疗后反应性充血介导的舒张活性明显增加(P〈0.01),硝酸甘油介导的舒张活性无明显变化(P〉0.05)。提示二甲双胍可改善肥胖IGT患者血管内皮功能,其机制可能为降血糖、血脂及抑制血管炎性因子水平。
机构地区 沂水中心医院
出处 《山东医药》 CAS 北大核心 2008年第29期72-73,共2页 Shandong Medical Journal
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