摘要
目的探讨葡萄糖耐量试验在空腹血糖正常高脂血症患者早期诊断糖尿病中的应用价值。方法选择秦皇岛市第四医院体检确诊的100例空腹血糖正常的单纯高脂血症患者,行葡萄糖耐量试验(OGTT),2 h后测定受检者2 h血糖(2hPG),分析葡萄糖耐量降低(IGT)及糖尿病检出情况,并比较正常组、IGT组及糖尿病组患者FPG、2hPG、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、谷草转氨酶(AST)、谷丙转氨酶(ALT)水平。结果 OGTT检出IGT 37例(37%),糖尿病27例(27%);IGT组及糖尿病组2hPG较正常组显著升高(P<0.05、P<0.01);三组TG、TC、LDL-C均高于正常值,糖尿病组TG、TC、LDL-C较正常组显著升高(P<0.05),而IGT组TG、TC、LDL-C与正常组差异无统计学意义(P>0.05);三组ALT及AST均在正常范围内,组间差异无统计学意义(P>0.05)。结论 OGTT试验可早期诊断空腹血糖正常的高脂血症患者的糖代谢异常,值得临床推广应用。
Objective To explore the application value of oral glucose tolerance test（OGTT） in the early diagnosis of diabetes in patients with hyperlipoidemia and normal fasting plasma glucose（FPG）. Methods One hundred patients with hyperlipoidemia and normal FPG were selected from the Fourth Hospital of Qinhuangdao.OGTT was performed in these patients,and then 2 h plasma glucose（2hPG） was determined.The diagnosed impaired glucose tolerance（IGT） and diabetes were observed,and the levels of FPG,2hPG,TC,TG,LDL-C,AST and ALT were compared among normal group,IGT group and diabetes group. Results The results of OGTT showed that there were 37（37%） cases of IGT and 27（27%） cases of diabetes.The 2hPG of IGT group and diabetes group was significantly higher than that of normal group（P0.05,P0.01）.TG,TC and LDL-C of the three groups were higher than the normal values,and those of diabetes group were significantly higher than those of normal group（P0.05）,but no statistically significant difference was observed in TG,TC and LDL-C between IGT group and normal group（P0.05）.ALT and AST of the three groups were within the normal values and no statistically significant difference was found among the three groups（P0.05）. Conclusions OGTT can early diagnose the abnormal glycometabolism of patients with hyperlipoidemia and normal FPG,and it is worthy of being extensively applied in clinic.
出处
《实用预防医学》
CAS
2012年第3期456-457,共2页
Practical Preventive Medicine
关键词
高脂血症
糖尿病
葡萄糖耐量试验
空腹血糖
Hyperlipoidemia
Diabetes
Oral glucose tolerance test
Fasting plasma glucose
