摘要
目的：探讨光学相干断层成像术（optical coherence tomography，OCT）检测近视眼视盘周同视网膜神经纤维层（refinal nerve fiber layer，RNFL）厚度的特点及其与屈光度的关系。方法：对5～40岁正常对照眼61例68眼，近视眼152例205眼，应用StratusOCTFM3000，RNFL3．4程序对视盘为中心直径3．4mm的RNFL进行检测。结果：近视眼RFNL厚度7：00和11：00位最大，3：00位最小，上象限（S）、下象限（I）平均值接近并〉颞侧象限平均值（T）〉鼻侧象限平均值（N）。正常眼组与低度、中度和高度近视眼组对应RNFL厚度相关参数组间比较：7：00和11：00，Smax，Imax，Smax／hnax，Max-Min差异均无显著性，3：00、4：00和N差异均有显著性。控制年龄因素条件下，近视眼RNFL厚度部分参数（上方和鼻侧居多）与等效球镜度数有较弱的负线性相关直线趋势，而部分参数（下方和颞侧居多）与等效球镜度数无直线性相关趋势。结论：近视眼视盘鼻侧RNFL厚度已变薄，中度和高度近视眼更明显，而颞侧和颞下RNFL变化不明显。
AIM： To evaluate the characteristics of peripapillary retinal nerve fibre layer （RNFL） thickness parameters and to investigate the relationship between RNFL thickness and the diopter in myopic Chinese subjects.
METHODS： The peripapillary RNFL of 205 myopic eyes and 68 normal control eyes with aged from 5 to 40 years were imaged on the Stratus OCTTM 3000. Thickness of the RNFL around the disc was determined with 3.4ram diameter circle OCT scan, and it was measured and analyzed using the RNFL thickness average analysis program. The data were analyzed using SPSS13.0 commercial statistical software.
RESULTS. （1） The thickest of RNFL was in 7 ： 00 and 11： 00, and the thinnest in 3 according clock type. The thickness of RNFL was thicker in the inferior quadrant （I） and the superior quadrant （S）, followed by the temporal quadrant （T）, and progressively less in nasal quadrant （N）. （2）All of the subjects whose age ranged from 5 to 40 years were divided into four groups, the normal subjects group （68 eyes）, the mild myopia group （-0.75D- - 3.00D, 68 eyes）, the moderate myopia group （-3.00D - - 6. 00D, 68 eyes）, the severe myopia group （≥-6.00D, 69 eyes）. The normal subjects group was as control group, and other three myopic groups compared with it. Some RNFLT parameters including 7： 00, 11： 00, Smax, Imax, Smax/Imax, and Max-Min had no statistically significant differences （P 〉 0. 05 ）. Some RNFLT para-meters including 3： 00, 4： 00, and N had statistically significant differences （P 〈 0.05）. （3）The results by partial correlation analysis of the relationship between the myopic diopter and the RNFLT parameters in the myopic eyes after the age factor was controlled, showed that some RNFLT parameters in the superior and nasal had negative correlation with diopter （ r = -0. 183 - -0. 362, P = 0. 009 - 0.000, P〈0.05）, but 3： 00, 7： 00, and 11： 00, Smax, Imax, Smax/Imax, and Max-Min did not have statistically significant correlation with diopter （ ｜r｜ = 0. 005 -0. 122, P= 0.942-0.082, P〉0.05）.
CONCLUSION： The reducing nasal RNFL thickness measured by OCT is detected in mild myopic Chinese subjects. And it is more obviously in the moderate and severe myopia of them. However, the reducing RNFL thickness is not significant in the temporal part and the temple-inferior part. The characteristics of the myopic RNFL thickness must be Considered carefully, when we identify the reducing RNFL thickness between subjects in myopia and patients in primary open angle glaucoma.
出处
《国际眼科杂志》
CAS
2008年第10期2044-2048,共5页
International Eye Science
