摘要
目的:建立5～18岁国人正常眼经光学相干断层成像术(OCT)检测的视盘周围视网膜神经纤维层(RNFL)厚度参考值范围;研究RNFL厚度各相关参数与眼别、性别的关系及其各参数的变异程度。方法:对75例5～18岁正常人135只正常眼,应用光学相干断层成像仪StratusOCTTM3000,采用RN-FL3.4程序对视盘为中心直径3.4mm的RNFL进行检测。资料的统计学处理应用SPSS10.0软件。结果:5～18岁国人正常眼1,2,～12各钟点位RN-FL厚度(μm)为134.43±27.62,88.74±21.78,57.82±11.72,76.47±16.57,120.52±22.53,154.48±26.19,159.34±20.68,88.01±17.10,66.28±9.96,97.70±16.17,148.81±19.29,147.00±25.77;上侧(Savg),鼻侧(Navg),下侧(Iavg),颞侧(Tavg)各象限厚度(μm)分别为143.42±16.41,74.36±13.75,144.75±16.46,83.96±12.12;全周平均厚度(Avg)111.63±9.58μm。不同眼别的1,2,8,10,11,12,Savg,Navg,Tavg,Smax/Tavg,Imax/Tavg,Smax/Navg组的均数间差异有显著性(｜t｜=2.490￣3.765,P=0.000￣0.016,P<0.05。不同性别相同眼别间,大部分对应的RNFL厚度相关参数间的差异无显著性(t=-1.702￣1.922,P=0.060￣0.894,P>0.05)。④各参数组变异系数(%):1,2,～12各钟点位依次为20.55,24.54,20.26,21.66,18.70,16.95,12.98,19.43,15.02,16.55,12.96,17.53;按Savg,Navg,Iavg,Tavg,Avg依次为11.44,18.50,11.37,14.53,8.58。结论:OCT检测5～18岁国人正常眼RNFL厚度钟点位中以6,7,11,12点较厚;Savg,Iavg接近并大于Tavg,Navg。不同眼别的RNFL厚度部分参数间差异有显著性,推测该差异与视网膜血管的管径大小及走行的不同有关。临床评估RNFL厚度检测结果时应考虑各参数变异程度不同的因素。
AIM： To quantitatively assess the normative reference values for peripapillary retinal nerve fiber layer （RNFL） thickness and to investigate the relationship between RNFL thickness and gender, right or left eye in Chinese subjects aging from 5 to 18 years with optical coherence tomography, so as to analyze the characteristics of the variation of the RNFL thickness parameters. METHODS： The RNFL of 135 eyes of 75 normal subjects （40 males and 35 females） was imaged on Stratus OCTTM 3000. Thickness of the RNFL around the disc was determined with 3.4mm diameter circle OCT scan. It was measured using the RNFL thickness average analysis program. The data was analyzed using SPSS10.0 commercial statistical software.
RESULTS： For the 135 subjects, the RNFL thickness （p m） according clock type （1, 2, …, 12） were 134.43± 27.62, 88.74 ± 21.78, 57.82 ± 11.72, 76.47 ± 16.57, 120.52± 22.53, 154.48± 26.19, 159.34± 20.68, 88.01± 17.10, 66.28± 9.96, 97.70± 16.17, 148.81± 19.29 and 147.00± 25.77; The average RNFL thickness（μm）in the superior, nasal, inferior and temporal quadrant were 143.42 ± 16.41,74.36 ± 13.75,144.75 ± 16.46,83.96 ± 12.12, and the mean of whole drcle was 111.63 ± 9.58μm. The difference of the mean of some RNFL thickness parameters, including the group of 1, 2, 8, 10, 11, 12, Savg, Navg, Tavg, Smax/Tavg, Tmax/Tavg and Smax/Navg, between fight eyes and left eyes was statistically significant （P=0.000-0.016, P〈0.05）. The difference of the bulk of various RNFL thickness parameters between of different gender was not statistically significant （P =0.060-0.894, P〉0.05）. the coefficient of variation （%） of the RNFL thickness parameters according clock type （1, 2, …, 12） were 20.55, 24.54, 20.26, 21.66, 18.70, 16.95, 12.98, 19.43, 15.02, 16.55, 12.96, 17.53, and it in the superior, nasal, inferior, temporal quadrant and the mean of whole drcle were 11.44, 18.50, 11.37, 14.53 and 8.58. CONCLUSTON： The RNFL is thickest in the inferior quadrant, followed by the superior quadrant, and progressively less in nasal and temporal quadrant. The difference between inferior and superior quadrants is not statistically significant. The difference of some RNFL thickness parameters between fight eyes and left eyes is significantly correlated with the difference of the diameter and track of retinal vessel. The RNFL thickness is not significantly correlated with gender. Tt is necessary to consider the difference of the coefficient of variation of the different RNFL thickness parameters in clinical praclice.
出处
《国际眼科杂志》
CAS
2006年第1期97-101,共5页
International Eye Science
关键词
视网膜神经纤维层
光学相干断层成像术
正常参考值
变异系数
retinal nerve fiber layer
optical coherence tomography
normative reference values
coefficient of variation
