摘要
以水杨酸和乙酸酐为原料,柠檬酸为催化剂合成阿司匹林,探讨了酸酐物质的量比、催化剂用量和反应时间、反应温度对产品收率的影响。研究结果表明,当酸酐物质的量比为1∶3,柠檬酸用量为1.0 g,反应时间为40 min,反应温度为70℃,纯化后阿司匹林收率达91.0%。
Aspirin was synthesized from salicylic acid and acetyl anhydride catalyzed by citric acid, and effect of rati, o of acid to anhydride, catalyst dose and reaction time on the yield of product was investigated. Result showed the yield of purified aspirin was 91.0% when the ratio of acid to anhydride was 1：3, citric acid dose was 1.0 g, and reacted at 70 ℃ for 40 min.
出处
《云南化工》
CAS
2008年第5期20-22,共3页
Yunnan Chemical Technology
关键词
阿司匹林
催化合成
柠檬酸
aspirin
catalytic synthesis
citric acid
